Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Li, L. et al. Nat. Chem. Biol. 10, 1043–1048 (2014).
STING polymer structure reveals mechanisms for activation, hyperactivation and inhibition
Ergun, SL, Fernandez, D., Weiss, T.M. and Li, L. Cell 178, 290–301 (2019)
SLC19A1 is an importer of the immunotransmitter cGAMP
Ritchie, C., Cordova, A. F., Hess, G. T., Bassik, M. C. & Li, L. Mol. Cell 75, 372–381 (2019).
Structural insights into STING signaling
Ergun, S.L. and Li, L. Trends in Cell Biol 30, 399-407 (2020).
Extracellular cGAMP is a cancer cell-produced immunotransmitter involved in radiation-induced anti-cancer immunity
Carozza JA, Böhnert V, Nguyen KC, Skariah G, Shaw KE, Brown JA, Rafat M, von Eyben R, Graves EE, Glenn JS, Smith M, Li L . Nat Cancer 1(2):184-196 (2020)
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Böhnert V, Maduke M, Bassik MC, Li L . Mol Cell 80(4):578-591 (2020)
Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes
Cordova, A.F., Ritchie, C. Bohnert, V. and Li, L. ACS Cent Sci. 7(6):1073-1088 (2021)
cGAMP as an Adjuvant in Antiviral Vaccines and Cancer Immunotherapy
Ritchie C, Li L. Biochemistry. 2020 May 12; 59(18):1713-1715. doi: 10.1021/acs.biochem.0c00226. Epub 2020 Apr 17.
Development of cGAMP-Luc, a sensitive and precise coupled enzyme assay to measure cGAMP in complex biological samples.
Mardjuki RE, Carozza JA, Li L. J Biol Chem. 2020 Apr 10; 295(15):4881-4892. doi: 10.1074/jbc.RA119.012170. Epub 2020 Mar 3